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Adapt drug inhibition #662

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tamslo opened this issue Sep 22, 2023 · 0 comments
Closed
10 tasks done

Adapt drug inhibition #662

tamslo opened this issue Sep 22, 2023 · 0 comments
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P: App Project: App Study: Must have T: Change Type: Changes

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@tamslo
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tamslo commented Sep 22, 2023

  • Divide inhibitor map into strong inhibitors and moderate inhibitors; moderate inhibitors with factor 0.5 (not used yet, see Implement moderate drug-gene inhibition #667)
  • Current functionality should only apply to strong inhibitors
  • Moderate inhibitors should only show wording ("can be influenced"; see Drug-drug interaction information)
    • No adaption of phenotype
    • Show warning if changing status
    • Show in drug detail if inhibiting drug
    • Show in drug detail (guideline part) if taking inhibiting drug (should use different wording*; implement in phenotypeFor)
    • Show as inhibiting drug in gene detail
  • Parotexine does not change itself (probably in general drugs that inhibit genes that metabolize themselves)
  • Only show message on report page if active inhibitors
  • Show original phenotype on gene page

* wording for different phenotype options:

  • No inhibitor taken: just original phenotype
  • Moderate inhibitor taken: $originalPhenotype (however, this can be influenced based on you taking $inhibitors)
  • Strong inhibitor taken: $overwrittenPhenotype ($originalPhenotype adjusted based on you taking $inhibitors)
  • Moderate and strong inhibitor taken: $overwrittenPhenotype ($originalPhenotype adjusted based on you taking $strongInhibitors; can additionally be influenced based on you taking $moderateInhibitors)
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Labels
P: App Project: App Study: Must have T: Change Type: Changes
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