Dynamical Network Biomarker 动态网络标志物

请注意，本项目可能不再维护!

本项目包含RNA-seq(转录组测序)、Chip-seq(染色质免疫共沉淀)，这两大类生物数据的动态网络标志物以及相关数据差异表达分析。

部分参考文献

• Aihara, K., et al. Dynamical network biomarkers: Theory and applications. Gene 2022;808:145997.
• Chen, L., et al. Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers. Sci Rep 2012;2:342.
• Guo, W.F., et al. Network control principles for identifying personalized driver genes in cancer. Brief Bioinform 2020;21(5):1641-1662.
• Liu, R., et al. Identifying critical transitions and their leading biomolecular networks in complex diseases. Sci Rep 2012;2:813.
• Liu, R., et al. Identifying critical transitions of complex diseases based on a single sample. Bioinformatics 2014;30(11):1579-1586.
• Liu, T.Y., et al. An individualized predictor of health and disease using paired reference and target samples. BMC Bioinformatics 2016;17:47.
• Liu, X., et al. Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers. BMC Med Genomics 2013;6 Suppl 2(Suppl 2):S8.
• Liu, X., et al. Personalized characterization of diseases using sample-specific networks. Nucleic Acids Res 2016;44(22):e164.
• Liu, Z.P., et al. Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains. BMC Syst Biol 2010;4 Suppl 2(Suppl 2):S11.