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Official PyTorch code for "Transformer-based out-of-distribution detection for clinically safe segmentation"

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Out-of-distribution detection with Transformers

This repo shows how a VQ-GAN + Transformer can be trained to perform unsupervised OOD detection on 3D medical data. It uses the freely available Medical Decathlon dataset for its experiments.

The method is fully described in the MIDL 2022 paper Transformer-based out-of-distribution detection for clinically safe segmentation.

Set-up

Create a fresh environment (this codebase was developed and tested with Python 3.8) and then install the required packages:

pip install -r requirements.txt

You can also build the docker image

cd docker/
bash create_docker_image.sh

Download and prepare the data

Download all classes of the Medical Decathlon dataset. NB: this will take a while.

export DATA_ROOT=/desired/path/to/data
python src/data/get_decathlon_datasets.py --data_root=${DATA_ROOT}

Train the VQ-GAN

We will treat the BRATs data as the in-distribution class and trained a VQ-GAN on it.

First set up your output dir:

export OUTPUT_DIR=/desired/path/to/output

Then train the VQ-GAN:

python train_vqvae.py \
--output_dir=${OUTPUT_DIR} \
--model_name=vqgan_decathlon \
--training_dir=${DATA_ROOT}/data_splits/Task01_BrainTumour_train.csv \
--validation_dir=${DATA_ROOT}/data_splits/Task01_BrainTumour_val.csv \
--n_epochs=300 \
--batch_size=8 \
--eval_freq=10 \
--cache_data=1 \
--vqvae_downsample_parameters=[[2,4,1,1],[2,4,1,1],[2,4,1,1],[2,4,1,1]] \
--vqvae_upsample_parameters=[[2,4,1,1,0],[2,4,1,1,0],[2,4,1,1,0],[2,4,1,1,0]] \
--vqvae_num_channels=[256,256,256,256] \
--vqvae_num_res_channels=[256,256,256,256] \
--vqvae_embedding_dim=128 \
--vqvae_num_embeddings=2048 \
--spatial_dimension=3 \
--image_roi=[160,160,128] \
--image_size=128 \
--num_workers=4

Code is DDP compatible. To train with N GPus, train with:

torchrun --nproc_per_node=N --nnodes=1 --node_rank=0 train_vqvae.py --args

Train the transformer

python train_transformer.py \
--output_dir=${OUTPUT_DIR}
--model_name=transformer_decathlon
--training_dir=${DATA_ROOT}/data_splits/Task01_BrainTumour_train.csv \
--validation_dir=${DATA_ROOT}/data_splits/Task01_BrainTumour_val.csv \
--n_epochs=100 \
--batch_size=4 \
--eval_freq=10 \
--cache_data=1 \
--image_roi=[160,160,128] \
--image_size=128 \
--num_workers=4
--vqvae_checkpoint=${OUTPUT_DIR}/vqgan_decathlon/checkpoint.pth
--transformer_type=transformer

Evaluate

Get likelihoods on the test set of the BRATs dataset, and on the test sets of the other 9 classes of the Medical Decathlon dataset.

python perform_ood.py \
--output_dir=${OUTPUT_DIR} \
--model_name=transformer_decathlon \
--training_dir=${DATA_DIR}/data_splits/Task01_BrainTumour_train.csv \
--validation_dir=${DATA_DIR}/data_splits/Task01_BrainTumour_val.csv \
--ood_dir=${DATA_DIR}/data_splits/Task01_BrainTumour_test.csv,${DATA_DIR}/data_splits/Task02_Heart_test.csv,${DATA_DIR}/data_splits/Task04_Hippocampus_test.csv,${DATA_DIR}/data_splits/Task05_Prostate_test.csv,${DATA_DIR}/data_splits/Task06_Lung_test.csv,${DATA_DIR}/data_splits/Task07_Pancreas_test.csv,${DATA_DIR}/data_splits/Task08_HepaticVessel_test.csv,${DATA_DIR}/data_splits/Task09_Spleen_test.csv,${DATA_DIR}/data_splits/Task10_Colon_test.csv
--cache_data=0
--batch_size=2
--num_workers=0
--vqvae_checkpoint=${OUTPUT_DIR}/vqgan_decathlon/checkpoint.pth
--transformer_checkpoint=${OUTPUT_DIR}/transformer_decathlon/checkpoint.pth
--transformer_type=transformer
--image_roi=[160,160,128]
--image_size=128

You can print the results with:

python print_ood_scores.py --results_file=${OUTPUT_DIR}/transformer_decathlon/results.csv

Acknowledgements

Built on top of MONAI Generative and MONAI.

Citation

If you use these codebase, please cite the following paper:

@inproceedings{graham2022transformer,
  title={Transformer-based out-of-distribution detection for clinically safe segmentation},
  author={Graham, Mark S and Tudosiu, Petru-Daniel and Wright, Paul and Pinaya, Walter Hugo Lopez and Jean-Marie, U and Mah, Yee H and Teo, James T and Jager, Rolf and Werring, David and Nachev, Parashkev and others},
  booktitle={International Conference on Medical Imaging with Deep Learning},
  pages={457--476},
  year={2022},
  organization={PMLR}
}

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Official PyTorch code for "Transformer-based out-of-distribution detection for clinically safe segmentation"

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