Overview

Overview:

The METATRYP tools are intended to help researchers answer questions about proteomics data.

Some specific questions that these tools help provide answers for include:

Is tryptic peptide XXX found in Proteome A and Proteome B? How many tryptic peptides do Proteome A and Proteome B have in common? Are tryptic peptides XXX and YYY both found in Proteome A? How many tryptic peptides are there in Proteome A that differ from peptide XXX by n positions?

Please note that this is not designed as a high-performance/high-volume solution; Instead it is intended to function as a quick-and-easy testing bed for doing computational analyses of proteomics data.

For higher volume instance of the METATRYP software with additional features (like Lowest Common Ancestor Analysis), please see METATRYP v. 2 (https://github.com/WHOIGit/metatryp-2.0). A web portal using a marine microbe database can be found at https://metatryp.whoi.edu/, and a portal using a coronavirus focuses database can be found at https://metatryp-coronavirus.whoi.edu/.

When using METATRYP v. 1 please cite the following: Saito, M.A., Dorsk, A., Post, A.F., McIlvin, M.R., Rappé, M.S., DiTullio, G.R. and Moran, D.M. (2015), Needles in the blue sea: Sub‐species specificity in targeted protein biomarker analyses within the vast oceanic microbial metaproteome. Proteomics, 15: 3521-3531. doi:10.1002/pmic.201400630