Skip to content

Commit

Permalink
Updated README with Biorxiv link and citation.
Browse files Browse the repository at this point in the history
  • Loading branch information
camiloaruiz committed May 11, 2020
1 parent 327e97b commit ed8316f
Showing 1 changed file with 19 additions and 7 deletions.
26 changes: 19 additions & 7 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -7,18 +7,19 @@

**The multiscale interactome is a powerful approach for the discovery of disease treatment mechanisms.** **(a)** The multiscale interactome models drug-disease treatments by integrating drugs, diseases, proteins, and functional pathways. **(b)** The diffusion profile of a drug or disease captures its effect on every protein and functional pathway. **(c)** By comparing the diffusion profiles of a drug and a disease, the multiscale interactome predicts whether the drug treats the disease, explains how the drug treats the disease, and explains how mutations interfere with the treatment mechanism to cause drug resistance or dangerous adverse reactions.

For a detailed description of the multiscale interactome and its applications, please refer to our preprint [Discovery of disease treatment mechanisms through the multiscale interactome](2020).
For a detailed description of the multiscale interactome and its applications, please refer to our preprint [Discovery of disease treatment mechanisms through the multiscale interactome](https://www.biorxiv.org/content/10.1101/2020.04.30.069690v1) (2020).

## Setup
Please install the packages present in the requirements.txt file. You may use:
## Data
All data is available at http://snap.stanford.edu/multiscale-interactome/data/data.tar.gz. To download the data, please run the following code in the same directory this project is cloned to. This should result in a data/ folder populated with the relevant data.
```
pip install -r requirements.txt
wget http://snap.stanford.edu/multiscale-interactome/data/data.tar.gz
tar -xvf data.tar.gz
```

Please download the data, using the commands below. This should result in a data/ folder populated with the relevant data. To download the data, run the following code in the same directory this project is cloned to:
## Setup
Code is written in Python3. Please install the packages present in the requirements.txt file. You may use:
```
wget http://snap.stanford.edu/multiscale-interactome/data/data.tar.gz
tar -xvf data.tar.gz
pip install -r requirements.txt
```

## Using the multiscale interactome
Expand Down Expand Up @@ -66,3 +67,14 @@ All data is provided at http://snap.stanford.edu/multiscale-interactome/data/dat

## Contact
Please contact Camilo Ruiz (caruiz@cs.stanford.edu) with any questions.

## Citation
```
@article{ruiz2020discovery,
title={Discovery of disease treatment mechanisms through the multiscale interactome},
author={Ruiz, Camilo and Zitnik, Marinka and Leskovec, Jure},
journal={bioRxiv},
year={2020},
publisher={Cold Spring Harbor Laboratory}
}
```

0 comments on commit ed8316f

Please sign in to comment.