Viktorian Miok
Comprehensive molecular characterisation of HPV-induced transformation by longitudinal statistical modelling
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The pdf version of this thesis can be accessed here.
I have done the work presented in this thesis in collaboration with the persons listed in each section. When using to information of this thesis, please cite the associated papers:
Chapter 1: Introduction
Background, data generation, and statistical analysis.
Chapter 2: tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities
Miok, V., Wilting, S. M., van de Wiel, M. A., Jaspers, A., van Noort, P. I., Brakenhoff, R. H., Snijders, P. J. F., Steenbergen, R. D. M. and van Wieringen, W. N. tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities, BMC Bioinformatics, (2014), 15: 327.
Chapter 3: Ridge estimation of the VAR(1) model and its time series chain graph from multivariate time-course omics data
Miok, V., Wilting, S. M. and van Wieringen, W. N. Ridge estimation of the VAR(1) model and its time series chain graph from multivariate time-course omics data, Biometrical Journal,(2017), 59(1), 172-191
Chapter 4: Ridge estimation of network models from time-course omics data
Miok, V., Wilting, S.M., van Wieringen, W.N. Ridge estimation of network models from time‐course omics data, Biometrical Journal, (2019), 61(2), 391-405.
Chapter 5: Comprehensive molecular profiling of HPV-induced transformation over time
Babion, I., Miok, V., Jaspers, A., Huseinovic, A., Steenbergen, R.D., van Wieringen, W.N., Wilting, S.M., Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation, Cancers, (2020), 12(3), 700.
Chapter 6: Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence
Wilting, S.M., Miok, V., Jaspers, A., Boon, D., Sorgard, H., Lando, M., Snoek, B.C., van Wieringen, W.N., Meijer, C.J., Lyng, H. and Snijders, P.J. Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence, Oncotarget, (2016), 7(28), 43805-43819
Chapter 7: Conclusion
Discussion and concluding remarks.
The figures in the introduction are my work. When using or adapting them, please cite this thesis as follows:
Viktorian, M. (2019). Comprehensive molecular characterisation of HPV-induced transformation by longitudinal statistical modelling
PhD-thesis is distributed under the GPL-3.0 License. Please read the license before using PhD-thesis, distributed in the LICENSE file.