![image](https://private-user-images.githubusercontent.com/20920507/307569558-94e954f6-9202-46e5-9a5a-c8c666301a1a.png?jwt=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.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.p57CH2jQUjMqZ09Fz3YjIqC-CO1uLnByiQbVzMmPwuE)
![image](https://private-user-images.githubusercontent.com/20920507/307569607-2bf29d7e-68c9-4044-a6d1-801fa5c44fbd.png?jwt=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.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.PzOTKXVoPgVQwPK4LiB4PZlDCoK6iaHd73j1J2PUepA)
Human placenta multi-omics analysis pipelines (snRNA-seq, snATAC-seq)
01.early_pregnancy_pipeline
02.late_pregnancy_pipeline
#Codes to analysis placenta multiomic data at early/late pregnancy. (Similar steps are omitted in late pregnancy)
03.In_vivo_in_vitro_comparison #Codes to compare in vitro and in vivo STB data.
04.ChIP-seq_and_cuttag_pipeline #Codes to analysis ChIP-seq and CUT&TAG datasets
Platform: Environment 1: R v3.6.3, python v3.8.5 Enrironment 2: R v4.1.3, python v3.10.5 (for GLUE integration, snapATACv2.2.0, pycistarget etc.)
[DOI: 10.5281/zenodo.10212321]
https://doi.org/10.5281/zenodo.10212321
Citation:
Wang, M. et al. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet 56, 294-305 (2024) https://doi.org/10.1038/s41588-023-01647-w