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Weighted HierArchical Benchmark Dose modeling for averaging meta dose-response data
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zhengzhou0105/WHALB
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WHALB is a platform for Weighted Hierarchical Bayesian Benchmark Dose. It incorporates model averaging of bayesian hierarchical models for benchmark dose modeling. All script are based on R software. Operatable under R_4.2.1 Rstan is required for Bayesian modeling in WHALB. Check out Rstan homepage: https://github.com/stan-dev/rstan/wiki/RStan-Getting-Started For use, please specify at the top of your script the following two directories: *mywd: the working directory where you want all the intermediate and output files to be stored. e.g. mywd = "C:/User/me/Working/" *fileDir: the source directory where R scripts and critical original data to be stored. e.g. fileDir = "C:/User/me/ImportantFiles/" *mywd and fileDir may be specified at the same directory. Both could accomendate HPC directories. Please contact the author for instructions. WHALB_model_utilites.R is required for all other scripts in this project. It contains basic utility functions. Please make sure all required R packages are installed. **WHALB_model_utilities.R must be stored in the fileDir directory** Folders are organized by components. * Continous: stan model script for fitting continous response data * Priors: the elicitation and specification of WHALB priors for models included: 1) Continous. * Model_Averaging: implementation and evaluation of averaging meta hierarchical models * Plotting: visual illustration of WHALB fits against orginal data points
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