GO:0048015 phosphatidylinositol-mediated signaling

[pgaudet]

GO:0048015 phosphatidylinositol-mediated signaling
Annotations are here:
https://docs.google.com/spreadsheets/d/1qQQS35lei6Roy-OtuxWhOx5ZEfLDXCIfaAq4b31SpVk/edit#gid=0

(43 EXP + 5 mappings)

[pgaudet]

Check if these can be annotated to the more specific term GO:0014065 phosphatidylinositol 3-kinase signaling

or if we need new terms

[pgaudet]

Mappings

• UniRule:UR000399976 > GO:phosphatidylinositol-mediated signaling ; GO:0048015
• InterPro:IPR008290 Phosphatidylinositol 3-kinase, Vps34 type > GO:phosphatidylinositol-mediated signaling ; GO:0048015
• InterPro:IPR015433 Phosphatidylinositol kinase > GO:phosphatidylinositol-mediated signaling ; GO:0048015
• InterPro:IPR028392 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain > GO:phosphatidylinositol-mediated signaling ; GO:0048015

[deustp01]

Annotations are here:

There is also one Reactome annotation, to a pathway R-HSA-198203 "PI3K/AKT activation". It could probably be switched to GO:0014065 phosphatidylinositol 3-kinase signaling if needed.

[pgaudet]

Hi @deustp01

Please move the annotation to GO:0043491 'phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction', which represents this specific signaling cassette.

Thanks, Pascale

[deustp01]

Done. The change will propagate to our public db with our next release, in September

[pfey03]

@pgaudet why are the dicty annotation listed that are not this terms but chemotaxis to cAMP and actin polymerisation? I won't change these

[pgaudet]

@pfey03 because these use the term in the extension - you have for e. g. chemotaxis to cAMP part of phosphatidylinositol-mediated signaling (which seems the wrong way around ?)

Thanks, Pascale

[pfey03]

ok, I see it now. It's often Bob''s annotations, but I change them usually

[pfey03]

@pgaudet GO:0014065 that you recommend above is an obsoleted term

[pfey03]

GO:0043491 protein kinase B signaling is a valid term but in QuickGo the term is phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction

[pgaudet]

@pfey03

GO:0014065 that you recommend above is an obsoleted term

Apologies.- too many moving parts!

GO:0043491 protein kinase B signaling

I thought this one was OK, since the abstract mentions PKB, I thought this might be the pathway they were testing?

[pfey03]

I need to read each paper as some annotation were pre P2GO. I have so many to change it will take a while

[pfey03]

I'm done with Dicty, most replaced and few deleted when there was the MF.

[pgaudet]

There are still about 4 annotations each by MGI and RGD.

[gthayman]

RGD done.

[LiNiMGI]

MGI done

[pgaudet]

@sarach06 @blazaropinto InterPro has not yet replied to this - were these mappings updated?

[sarach06]

Dear Pascale,
Apologies for the slow reply! I have removed the term from these entries, which will be visible in the next release (InterPro 96.0).
Best wishes,
Sara

[pgaudet]

Thanks!