merged terms fixes #13002

src/ontology/go-edit.obo

@@ -7144,15 +7144,17 @@ creation_date: 2011-01-27T03:42:53Z
 
 [Term]
 id: GO:0000987
-name: proximal promoter sequence-specific DNA binding
+name: cis-regulatory region sequence-specific DNA binding
 namespace: molecular_function
+alt_id: GO:0001158
 alt_id: GO:0001159
-def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter." [GOC:pg, GOC:txnOH]
-comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
-synonym: "core promoter proximal region DNA binding" RELATED []
-synonym: "core promoter proximal region sequence-specific DNA binding" EXACT []
-synonym: "promoter proximal region sequence-specific DNA binding" EXACT []
+synonym: "core promoter proximal region DNA binding" NARROW []
+synonym: "core promoter proximal region sequence-specific DNA binding" NARROW []
+synonym: "enhancer sequence-specific DNA binding" RELATED []
+synonym: "promoter proximal region sequence-specific DNA binding" NARROW []
+synonym: "proximal promoter sequence-specific DNA binding" NARROW []
 is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
+is_a: GO:0035326 ! cis-regulatory region binding
 created_by: kchris
 creation_date: 2010-08-10T03:40:16Z
 
@@ -8587,16 +8589,6 @@ is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor bi
 created_by: kchris
 creation_date: 2011-01-27T05:02:22Z
 
-[Term]
-id: GO:0001158
-name: enhancer sequence-specific DNA binding
-namespace: molecular_function
-def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
-is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
-is_a: GO:0035326 ! enhancer binding
-created_by: kchris
-creation_date: 2011-01-28T03:29:40Z
-
 [Term]
 id: GO:0001160
 name: transcription termination site DNA binding
@@ -210473,9 +210465,10 @@ creation_date: 2010-02-26T10:11:55Z
 
 [Term]
 id: GO:0035326
-name: enhancer binding
+name: cis-regulatory region binding
 namespace: molecular_function
 def: "Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:sart, GOC:txnOH, SO:0000165]
+synonym: "enhancer binding" RELATED []
 is_a: GO:0044212 ! transcription regulatory region DNA binding
 created_by: rfoulger
 creation_date: 2010-02-26T10:17:00Z